Joseph J Cullen Selected Research

Dicumarol (Dicoumarol)

7/2017	Targeting NAD(P)H:Quinone Oxidoreductase (NQO1) in Pancreatic Cancer.
12/2006	Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells.
8/2005	Targeting NAD(P)H:quinone oxidoreductase (NQO1) in pancreatic cancer.
7/2004	Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress.
9/2003	Dicumarol inhibition of NADPH:quinone oxidoreductase induces growth inhibition of pancreatic cancer via a superoxide-mediated mechanism.

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Joseph J Cullen Research Topics

Disease

42	Neoplasms (Cancer) 05/2022 - 03/2003
34	Pancreatic Neoplasms (Pancreatic Cancer) 05/2022 - 01/2003
5	Infections 02/2010 - 10/2000
3	Glioblastoma (Glioblastoma Multiforme) 01/2021 - 10/2017
3	Neoplasm Metastasis (Metastasis) 10/2020 - 07/2011
3	Adenocarcinoma 12/2018 - 03/2003
3	Breast Neoplasms (Breast Cancer) 02/2010 - 12/2006
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 10/2017
2	Colonic Neoplasms (Colon Cancer) 01/2020 - 01/2018
2	Chronic Pancreatitis 03/2003 - 01/2003
1	Rheumatoid Arthritis 05/2022
1	Pain (Aches) 01/2022
1	Chronic Pain 01/2022
1	Chills 11/2019
1	Anemia 01/2018
1	Stomach Neoplasms (Stomach Cancer) 01/2018
1	Hypoxia (Hypoxemia) 04/2014
1	Pneumonia (Pneumonitis) 08/2011
1	Heart Failure 08/2011
1	Sepsis (Septicemia) 08/2011
1	Weight Loss (Weight Reduction) 11/2008
1	Hemorrhage 11/2008
1	Pathologic Constriction (Stenosis) 11/2008
1	Nausea 11/2008
1	Vomiting 11/2008
1	Prostatic Neoplasms (Prostate Cancer) 07/2008

Drug/Important Bio-Agent (IBA)

11	Superoxide DismutaseIBA 08/2017 - 03/2003
9	AntioxidantsIBA 05/2022 - 01/2003
9	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 10/2021 - 03/2004
8	Ascorbic Acid (Vitamin C)FDA LinkGeneric 10/2020 - 04/2010
8	Superoxides (Superoxide)IBA 08/2017 - 09/2003
7	CatalaseIBA 04/2021 - 01/2003
7	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2021 - 01/2003
6	EnzymesIBA 12/2007 - 01/2003
5	IronIBA 01/2021 - 01/2013
5	Dicumarol (Dicoumarol)FDA Link 07/2017 - 09/2003
5	Proteins (Proteins, Gene)FDA Link 12/2007 - 03/2003
4	PeroxidesIBA 05/2022 - 05/2009
4	Gemcitabine FDA Link 12/2018 - 06/2011
4	NAD (NADH)IBA 07/2017 - 09/2003
4	Oxidoreductases (Dehydrogenase)IBA 07/2017 - 09/2003
4	quinone (benzoquinone)IBA 07/2017 - 09/2003
4	Glutathione PeroxidaseIBA 01/2005 - 01/2003
3	NADP (NADPH)IBA 07/2013 - 09/2003
3	Complementary DNA (cDNA)IBA 02/2010 - 09/2003
3	ZincIBA 12/2007 - 03/2003
3	CopperIBA 12/2007 - 03/2003
3	AgarIBA 01/2006 - 04/2003
2	Indicators and Reagents (Reagents)IBA 04/2021 - 12/2016
2	Temozolomide (Temodar)FDA LinkGeneric 01/2021 - 11/2019
2	Saccharated Ferric Oxide (Venofer)FDA Link 01/2020 - 01/2018
2	tetrakis(N- methyl- 4- pyridiniumyl)porphine manganese(III) complexIBA 01/2019 - 08/2013
2	ProdrugsIBA 01/2018 - 12/2012
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2018 - 04/2014
2	Streptonigrin (Nigrin)IBA 07/2017 - 08/2005
2	Biological ProductsIBA 07/2011 - 07/2008
2	Carmustine (FIVB)FDA Link 02/2010 - 05/2009
2	Small Interfering RNA (siRNA)IBA 02/2010 - 12/2007
2	GelsIBA 01/2005 - 03/2003
1	ThioredoxinsIBA 05/2022
1	Auranofin (Ridaura)FDA Link 05/2022
1	Opioid Analgesics (Opioids)IBA 01/2022
1	PlatinumIBA 01/2022
1	Radiation-Sensitizing AgentsIBA 10/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	AcidsIBA 01/2020
1	Arachidonate 12-Lipoxygenase (12 Lipoxygenase)IBA 01/2020
1	MitogensIBA 01/2020
1	Pharmaceutical PreparationsIBA 11/2019
1	CollagenIBA 12/2018
1	Cisplatin (Platino)FDA LinkGeneric 01/2018
1	Carboplatin (JM8)FDA LinkGeneric 01/2018
1	IonsIBA 01/2018
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2018
1	Irinotecan (Camptosar)FDA LinkGeneric 01/2018
1	Fluorouracil (Carac)FDA LinkGeneric 01/2018
1	MetalsIBA 01/2018
1	ThymidineIBA 01/2016
1	Oxygen (Dioxygen)IBA 04/2014
1	Transcription Factors (Transcription Factor)IBA 04/2014
1	hydroethidineIBA 07/2013
1	tempolIBA 07/2013
1	LuciferasesIBA 07/2011
1	Tumor Suppressor Protein p14ARF (p14ARF)IBA 07/2011
1	Doxorubicin (Adriamycin)FDA LinkGeneric 05/2009
1	Mitochondrial DNA (mtDNA)IBA 05/2009
1	Ethidium (Ethidium Bromide)IBA 05/2009

Therapy/Procedure

11	Therapeutics 05/2022 - 07/2004
6	Drug Therapy (Chemotherapy) 01/2022 - 01/2005
6	Injections 04/2014 - 04/2003
4	Radiotherapy 11/2019 - 01/2005
2	Intravenous Administration 01/2019 - 01/2018
2	Intravenous Infusions 01/2019 - 12/2018
2	Length of Stay 12/2006 - 10/2000
1	Perioperative Care 01/2022
1	Immunotherapy 01/2022
1	Combined Modality Therapy 01/2019
1	Artificial Respiration (Mechanical Ventilation) 08/2011
1	Total Parenteral Nutrition 11/2008
1	Gastroplasty (Vertical-Banded Gastroplasty) 11/2008